Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol.

@article{Labrecque2003RegulationOV,
  title={Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol.},
  author={Lyne Labrecque and Isabelle Royal and David S Surprenant and C. G. Patterson and Denis Gingras and Richard B{\'e}liveau},
  journal={Molecular biology of the cell},
  year={2003},
  volume={14 1},
  pages={
          334-47
        }
}
The stimulation of vascular endothelial growth factor receptor-2 (VEGFR-2) by tumor-derived VEGF represents a key event in the initiation of angiogenesis. In this work, we report that VEGFR-2 is localized in endothelial caveolae, associated with caveolin-1, and that this complex is rapidly dissociated upon stimulation with VEGF. The kinetics of caveolin-1 dissociation correlated with those of VEGF-dependent VEGFR-2 tyrosine phosphorylation, suggesting that caveolin-1 acts as a negative… CONTINUE READING
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