Regulation of vascular endothelial growth factor binding and activity by extracellular pH.

@article{Goerges2003RegulationOV,
  title={Regulation of vascular endothelial growth factor binding and activity by extracellular pH.},
  author={Adrienne L Goerges and Matthew A. Nugent},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 21},
  pages={19518-25}
}
Angiogenesis, the growth of new blood vessels, is regulated by a number of factors, including hypoxia and vascular endothelial growth factor (VEGF). Although the effects of hypoxia have been studied intensely, less attention has been given to other extracellular parameters such as pH. Thus, the present study investigates the consequences of acidic pH on VEGF binding and activity in endothelial cell cultures. We found that the binding of VEGF165 and VEGF121 to endothelial cells increased as the… CONTINUE READING