Regulation of vacuolar proton-translocating ATPase activity and assembly by extracellular pH.

@article{Diakov2010RegulationOV,
  title={Regulation of vacuolar proton-translocating ATPase activity and assembly by extracellular pH.},
  author={Theodore T. Diakov and Patricia M Kane},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 31},
  pages={23771-8}
}
Vacuolar proton-translocating ATPases (V-ATPases) are responsible for organelle acidification in all eukaryotic cells. The yeast V-ATPase, known to be regulated by reversible disassembly in response to glucose deprivation, was recently reported to be regulated by extracellular pH as well (Padilla-López, S., and Pearce, D. A. (2006) J. Biol. Chem. 281, 10273-10280). Consistent with those results, we find 57% higher V-ATPase activity in vacuoles isolated after cell growth at extracellular pH of 7… CONTINUE READING