Regulation of uterine smooth muscle bradykinin receptors by bradykinin levels and angiotensin converting enzyme inhibitor in the rat.

Abstract

1. Bradykinin infusion (0.1 microgram/min i.v.) decreased the number of uterine bradykinin receptors by 20% at Day 2. Bradykinin receptors returned to control levels at Day 7. 2. Captopril infusion (1.7 micrograms/min i.v.) induced prolonged decreases in the number of uterine bradykinin receptors of 15% at Day 2 and of 13% at Day 7, respectively. 3. The number of uterine bradykinin receptors was increased in two-kidney, one clip hypertensive rats by 19%. 4. These results suggest that endogenous bradykinin participates in the regulation of uterine bradykinin receptors. 5. Decreased uterine bradykinin receptors induced by captopril might reflect increased endogenous bradykinin.

Cite this paper

@article{Yasujima1981RegulationOU, title={Regulation of uterine smooth muscle bradykinin receptors by bradykinin levels and angiotensin converting enzyme inhibitor in the rat.}, author={Minoru Yasujima and Paul G. Matthews and Colin I. Johnston}, journal={Clinical and experimental pharmacology & physiology}, year={1981}, volume={8 5}, pages={515-8} }