Regulation of urokinase-type plasminogen activator expression by the v-mos oncogene.

@article{Lengye1995RegulationOU,
  title={Regulation of urokinase-type plasminogen activator expression by the v-mos oncogene.},
  author={E Lengye and Balraj Singh and Rebecca Gum and Claus Nerlov and Anita L. Sabichi and Michael Birrer and Douglas Boyd},
  journal={Oncogene},
  year={1995},
  volume={11 12},
  pages={2639-48}
}
We undertook a study to determine if the serine-threonine kinase-encoding v-mos oncogene regulated the expression of the urokinase-type plasminogen activator. An expression vector encoding v-mos, but not a kinase-inactive mutant, stimulated urokinase promoter activity in CAT assays employing a squamous cell carcinoma cell line. The induction of urokinase promoter activity by v-mos was mediated, in part, via an increased AP-1 activity since (a) mutation of 2 AP-1 binding sites (at -1967 and… CONTINUE READING