Regulation of urokinase plasminogen activator/plasmin-mediated invasion of melanoma cells by the integrin vitronectin receptor alphaVbeta3.

@article{Khatib2001RegulationOU,
  title={Regulation of urokinase plasminogen activator/plasmin-mediated invasion of melanoma cells by the integrin vitronectin receptor alphaVbeta3.},
  author={A M Khatib and John Nip and Lucia Fallavollita and Maxime M-A Lehmann and Gitte S. Jensen and Pnina Brodt},
  journal={International journal of cancer},
  year={2001},
  volume={91 3},
  pages={300-8}
}
The integrin vitronectin receptor alphavbeta3 is a mediator of cellular migration and invasion and has been identified as a marker of progression in malignant melanoma. Using a human melanoma model, we have previously shown that this receptor was coordinately expressed with the receptor for the urokinase plasminogen activator (uPAR). In our present study, the link between these receptors was further investigated by assessing the effect of alphavbeta3 ligation on uPAR transcription and function… CONTINUE READING
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