Regulation of ubiquitin-proteasome system mediated degradation by cytosolic stress.

@article{Kelly2007RegulationOU,
  title={Regulation of ubiquitin-proteasome system mediated degradation by cytosolic stress.},
  author={Sean Michael Kelly and Judy K Vanslyke and Linda S. Musil},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 11},
  pages={
          4279-91
        }
}
ER-associated, ubiquitin-proteasome system (UPS)-mediated degradation of the wild-type (WT) gap junction protein connexin32 (Cx32) is inhibited by mild forms of cytosolic stress at a step before its dislocation into the cytosol. We show that the same conditions (a 30-min, 42 degrees C heat shock or oxidative stress induced by arsenite) also reduce the… CONTINUE READING