Regulation of ubiquitin-proteasome pathway on pig oocyte meiotic maturation and fertilization.

@article{Huo2004RegulationOU,
  title={Regulation of ubiquitin-proteasome pathway on pig oocyte meiotic maturation and fertilization.},
  author={L. Gao-Y. Zhou-C. Li-L. Huo and Heng-Yu Fan and Cheng-Guang Liang and Ling-Zhu Yu and Zhi-Sheng Zhong and Da-Yuan Chen and Qing-Yuan Sun},
  journal={Biology of reproduction},
  year={2004},
  volume={71 3},
  pages={853-62}
}
Degradation of proteins mediated by the ubiquitin-proteasome pathway (UPP) plays essential roles in the eukaryotic cell cycle. The main aim of the present study was to analyze the functional roles and regulatory mechanisms of the UPP in pig oocyte meiotic maturation, activation, and early embryo mitosis by drug treatment, Western blot analysis, and confocal microscopy. By using the hypoxanthine-maintained meiotic arrest model, we showed that the meiotic resumption of both cumulus-enclosed… CONTINUE READING
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