Regulation of ubiquitin chain initiation to control the timing of substrate degradation.

@article{Williamson2011RegulationOU,
  title={Regulation of ubiquitin chain initiation to control the timing of substrate degradation.},
  author={Adam Williamson and Sudeep Banerjee and Xining Zhu and Isabelle Philipp and Anthony T. Iavarone and Michael Rape},
  journal={Molecular cell},
  year={2011},
  volume={42 6},
  pages={744-57}
}
Processive reactions, such as transcription or translation, often proceed through distinct initiation and elongation phases. The processive formation of polymeric ubiquitin chains can accordingly be catalyzed by specialized initiating and elongating E2 enzymes, but the functional significance for this division of labor has remained unclear. Here, we have identified sequence motifs in several substrates of the anaphase-promoting complex (APC/C) that are required for efficient chain initiation by… CONTINUE READING

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