Regulation of tyrosinase in human melanocytes grown in culture

@article{Halaban1983RegulationOT,
  title={Regulation of tyrosinase in human melanocytes grown in culture},
  author={Ruth Halaban and Seymour H. Pomerantz and S. W. Marshall and Drew T. Lambert and Aaron B. Lerner},
  journal={The Journal of Cell Biology},
  year={1983},
  volume={97},
  pages={480 - 488}
}
Tyrosinase, the enzyme that controls the synthesis of melanin, is a unique product of melanocytes. Normal and malignant human melanocytes grown in culture were used to study the factors that regulate the expression of tyrosinase. Immunoprecipitation experiments showed that newly synthesized tyrosinase appeared as a protein with an apparent molecular weight of 70,000 that was processed to a protein with an apparent molecular weight of 80,000. Neither tunicamycin nor 2-deoxy-D-glucose inhibited… CONTINUE READING

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References

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Showing 1-9 of 9 references

MSH-responsive adenyl cyclase in the Cloudman S-91 melanoma

M. W. Bitensky, H. B. Demopoulos, V. Russell
Des Moines • 1972
View 15 Excerpts
Highly Influenced

Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin.

Proceedings of the National Academy of Sciences of the United States of America • 1982
View 3 Excerpts
Highly Influenced

Genetic and biochemical studies on pigmented hybrid cells that overexpress tyrosinase

R. Halaban, Y. Milner, +3 authors A. B. Lerner
1981
View 2 Excerpts

Electrophoretic variation of tyrosinase in follicular melanocyles during the hair growth cycle in mice..L Exp

J. B. Buruett, T. J. Holstein, W. C. Quevedo, Jr.
Zoo/ • 1969
View 2 Excerpts

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