Regulation of tyrosinase in human melanocytes grown in culture

  title={Regulation of tyrosinase in human melanocytes grown in culture},
  author={Ruth Halaban and Seymour H. Pomerantz and S. W. Marshall and Drew T. Lambert and Aaron B. Lerner},
  journal={The Journal of Cell Biology},
  pages={480 - 488}
Tyrosinase, the enzyme that controls the synthesis of melanin, is a unique product of melanocytes. Normal and malignant human melanocytes grown in culture were used to study the factors that regulate the expression of tyrosinase. Immunoprecipitation experiments showed that newly synthesized tyrosinase appeared as a protein with an apparent molecular weight of 70,000 that was processed to a protein with an apparent molecular weight of 80,000. Neither tunicamycin nor 2-deoxy-D-glucose inhibited… CONTINUE READING


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