Regulation of type III secretion in Bordetella.

  title={Regulation of type III secretion in Bordetella.},
  author={Suneel Mattoo and Ming H. Yuk and Lisa L. Huang and Jeff Miller},
  journal={Molecular microbiology},
  volume={52 4},
The BvgAS virulence control system regulates the expression of type III secretion genes in Bordetella subspecies that infect humans and other mammals. We have identified five open reading frames, btrS, btrU, btrX, btrW and btrV, that are activated by BvgAS and encode regulatory factors that control type III secretion at the levels of transcription, protein expression and secretion. The btrS gene product bears sequence similarity to ECF (extracytoplasmic function) sigma factors and is required… CONTINUE READING


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