Regulation of type-II calmodulin kinase: Functional implications

  title={Regulation of type-II calmodulin kinase: Functional implications},
  author={Jeff M. Bronstein and Debora B Farber and Claude Guy Wasterlain},
  journal={Brain Research Reviews},
Calmodulin-kinase II (CaM kinase) is a calcium/calmodulin-dependent protein kinase which is highly enriched in the nervous system and mediates many of calcium's actions. Regulation of CaM kinase activity plays an important role in modulating synaptic transmission, synaptic plasticity and in neuropathology. Primary regulation of CaM kinase occurs via changes in intracellular calcium concentrations. Increased calcium stimulates protein kinase activity and induces autophosphorylation… CONTINUE READING


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