Regulation of type I interferon responses

@article{Ivashkiv2013RegulationOT,
  title={Regulation of type I interferon responses},
  author={Lionel B Ivashkiv and Laura T. Donlin},
  journal={Nature Reviews Immunology},
  year={2013},
  volume={14},
  pages={36-49}
}
Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. Canonical type I IFN signalling activates the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway, leading to transcription of IFN-stimulated genes (ISGs). Host, pathogen and environmental factors regulate the responses of cells to this signalling pathway and thus calibrate host defences while limiting tissue damage and… CONTINUE READING
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