Regulation of type I adenylyl cyclase by calmodulin kinase IV in vivo.

@article{Wayman1996RegulationOT,
  title={Regulation of type I adenylyl cyclase by calmodulin kinase IV in vivo.},
  author={Gary A. Wayman and Jianning Wei and Steven K. Wong and Daniel R Storm},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 11},
  pages={6075-82}
}
Type I adenylyl cyclase is a neurospecific enzyme that is stimulated by Ca2+ and calmodulin (CaM). This enzyme couples the Ca2+ and cyclic AMP (cAMP) regulatory systems in neurons, and it may play an important role for some forms of synaptic plasticity. Mutant mice lacking type I adenylyl cyclase show deficiencies in spatial memory and altered long-term potentiation (Z. Wu, S. A. Thomas, Z. Xia, E. C. Villacres, R. D. Palmiter, and D. R. Storm, Proc. Natl. Acad. Sci. USA 92:220-224, 1995… CONTINUE READING

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