Regulation of tumour necrosis factor signalling: live or let die

@article{Brenner2015RegulationOT,
  title={Regulation of tumour necrosis factor signalling: live or let die},
  author={Dirk Brenner and Heiko Blaser and Tak Wah Mak},
  journal={Nature Reviews Immunology},
  year={2015},
  volume={15},
  pages={362-374}
}
Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) signalling is associated with many inflammatory disorders, including various types of arthritis and inflammatory bowel disease, and targeting TNF has been an effective therapeutic strategy in these diseases. This Review focuses on the recent advances that have been made in understanding TNFR signalling and the consequences of… 
Tumour necrosis factor signalling in health and disease
TLDR
There have been significant advances in the understanding of T NF signalling pathways in the last decade, and this short review aims to elucidate some of the most recent advances involving TNF signalling in health and disease.
TNF in the liver: targeting a central player in inflammation.
TLDR
Considering these multiple functions of TNF in the liver, this work proposes anti-TNF therapies that specifically target TNF signalling at the level of its specific receptors.
TNF biology, pathogenic mechanisms and emerging therapeutic strategies
TLDR
Molecular mechanisms underlying the roles of T NF in homeostasis and inflammatory disease pathogenesis are presented, and novel strategies to advance therapeutic paradigms for the treatment of TNF-mediated diseases are discussed.
Dysregulation of Cell Death in Human Chronic Inflammation.
TLDR
Patients with PIDs have revealed paradoxical connections between immunodeficiency, chronic inflammation, and dysregulated cell death, and studies on PIDs may help to predict beneficial effects and side-effects of therapeutic targeting of TNFR1 signaling.
The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics
TLDR
The impact of TNF-α signaling on autoimmune diseases and its inhibitors, which are used as therapeutic agents against autoimmune diseases, are briefly introduced.
Insights into the biology and therapeutic implications of TNF and regulatory T cells
  • B. Salomon
  • Biology, Medicine
    Nature Reviews Rheumatology
  • 2021
TLDR
The complex pro-inflammatory and regulatory roles of TNF are reviewed, highlighting its effects on the expansion, differentiation and suppressive function of regulatory T cells and their implications for the design of future anti-TNF agents.
TNFR signalling and its clinical implications
Transition from TNF-Induced Inflammation to Death Signaling.
TLDR
RARγ provides a checkpoint for the transition from inflammatory signaling to death machinery of RIPK1-initiated cell death in response to TNF, and is identified as a downstream mediator of TNFR1 signaling complex.
Tumor necrosis factor receptor-2 (TNFR2): an overview of an emerging drug target
TLDR
With respect to its preference for Treg stimulation and protection of non-immune cells, TNFR2 is more unique and thus offers opportunities for translational success, and this approach is just one amongst many suitable targets.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 185 REFERENCES
TNF‐mediated inflammatory disease
  • J. Bradley
  • Biology, Medicine
    The Journal of pathology
  • 2008
TLDR
The central role of TNF in inflammation has been demonstrated by the ability of agents that block the action of T NF to treat a range of inflammatory conditions, including rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease and psoriasis.
Signalling pathways of the TNF superfamily: a double-edged sword
  • B. Aggarwal
  • Biology, Medicine
    Nature Reviews Immunology
  • 2003
TLDR
Two different tumour-necrosis factors, first isolated in 1984, were found to be cytotoxic to tumour cells and to induce tumour regression in mice, and blockers of TNF have been approved for human use in treating TNF-linked autoimmune diseases.
Regulation of TNF‐α with a focus on rheumatoid arthritis
TLDR
The role and regulation of the major proinflammatory cytokine TNF‐α, in particular the regulation of T NF‐α production, post‐translational processing and signaling of TNF-α and its receptors are discussed.
Anti-TNF-α therapies: the next generation
TLDR
This review discusses briefly the present understanding of TNF-α-mediated biology and the current injectable therapies in clinical use, and focuses on some of the new therapeutic approaches with oral, small-molecule inhibitors.
Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors
TLDR
Tumor necrosis factor receptor 1-associated death domain protein (TRADD) is the core adaptor recruited to TNF receptor 1 (TNFR1) upon TNFα stimulation and has a novel role in TLR3 and TLR4 signaling.
RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
TLDR
The protein kinase receptor-interacting protein 3 (RIP3) was identified as a molecular switch between TNF-induced apoptosis and necrosis in NIH 3T3 cells and found that RIP3 was required for necrosisin other cells.
Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE
TLDR
It is reported that iRhom2 (RHBDF2), a proteolytically inactive member of the rhomboid family, is required for TNF release in mice and may represent an attractive therapeutic target.
...
1
2
3
4
5
...