Regulation of tumour necrosis factor signalling: live or let die

  title={Regulation of tumour necrosis factor signalling: live or let die},
  author={D. Brenner and H. Blaser and T. Mak},
  journal={Nature Reviews Immunology},
  • D. Brenner, H. Blaser, T. Mak
  • Published 2015
  • Medicine
  • Nature Reviews Immunology
  • Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) signalling is associated with many inflammatory disorders, including various types of arthritis and inflammatory bowel disease, and targeting TNF has been an effective therapeutic strategy in these diseases. This Review focuses on the recent advances that have been made in understanding TNFR signalling and the consequences of… CONTINUE READING
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