Regulation of tumour necrosis factor (TNF) induced apoptosis by soluble TNF receptors in Helicobacter pylori infection.

@article{Shibata1999RegulationOT,
  title={Regulation of tumour necrosis factor (TNF) induced apoptosis by soluble TNF receptors in Helicobacter pylori infection.},
  author={Junsuke Shibata and Hidemi Goto and Tomiyasu Arisawa and Yasumasa Niwa and Tetsuo Hayakawa and Akie Nakayama and Naoyoshi Mori},
  journal={Gut},
  year={1999},
  volume={45 1},
  pages={24-31}
}
BACKGROUND Tumour necrosis factor (TNF) is a predominant cytokine produced in the gastric mucosa of patients with Helicobacter pylori infection. TNF induces apoptosis in a variety of cells. The soluble TNF receptors (sTNF-Rs) can be divided into sTNF-RI and sTNF-RII, both of which inhibit TNF activity. However, their precise mechanisms remain unclear. AIM To investigate the role of sTNF-Rs in H pylori infection. METHODS In 40 patients, production of TNF and sTNF-Rs in gastric mucosa was… CONTINUE READING

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