Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt.

@article{Zhang2001RegulationOT,
  title={Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt.},
  author={Huang-ge Zhang and Yumei Wang and Jun Fang Xie and Xinjun Liang and D I Liu and P A Yang and H C Hsu and Ratna B Ray and John D. Mountz},
  journal={Arthritis and rheumatism},
  year={2001},
  volume={44 7},
  pages={1555-67}
}
OBJECTIVE To determine if tumor necrosis factor alpha (TNFalpha)-driven proliferation of rheumatoid arthritis synovial fibroblasts (RASF) is associated with up-regulation of the activity of serine/threonine kinase B/Akt and with survival of RASF. METHODS Staining of phosphorylated Akt was done using anti-phosphorylated Thr308 Akt antibody. Levels of phosphorylated Akt were analyzed by Western blot and Akt activity was analyzed using a kinase assay. TUNEL staining was used to analyze the… CONTINUE READING
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