Regulation of tubulin levels and microtubule assembly in Saccharomyces cerevisiae: consequences of altered tubulin gene copy number.

@article{Katz1990RegulationOT,
  title={Regulation of tubulin levels and microtubule assembly in Saccharomyces cerevisiae: consequences of altered tubulin gene copy number.},
  author={Wendy S. Katz and Boris Weinstein and F D Paul Solomon},
  journal={Molecular and cellular biology},
  year={1990},
  volume={10 10},
  pages={5286-94}
}
Microtubule organization in the cytoplasm is in part a function of the number and length of the assembled polymers. The intracellular concentration of tubulin could specify those parameters. Saccharomyces cerevisiae strains constructed with moderately decreased or increased copy numbers of tubulin genes provide an opportunity to study the cellular response to a steady-state change in tubulin concentration. We found no evidence of a mechanism for adjusting tubulin concentrations upward from a… CONTINUE READING
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