Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein

  title={Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein},
  author={Jason C. Bermak and Ming Li and Clayton M. Bullock and Qun Zhou},
  journal={Nature Cell Biology},
Many structural determinants for G protein-coupled receptor (GPCR) functions have been defined, but little is known concerning the regulation of their transport from the endoplasmic reticulum (ER) to the cell surface. Here we show that a carboxy-terminal hydrophobic motif, FxxxFxxxF, which is highly conserved among GPCRs, functions independently as an ER-export signal for the dopamine D1 receptor. A newly identified ER-membrane-associated protein, DRiP78, binds to this motif. Overexpression or… 

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