Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein

@article{Bermak2001RegulationOT,
  title={Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein},
  author={Jason C. Bermak and Ming Li and Clayton M. Bullock and Qun Zhou},
  journal={Nature Cell Biology},
  year={2001},
  volume={3},
  pages={492-498}
}
Many structural determinants for G protein-coupled receptor (GPCR) functions have been defined, but little is known concerning the regulation of their transport from the endoplasmic reticulum (ER) to the cell surface. Here we show that a carboxy-terminal hydrophobic motif, FxxxFxxxF, which is highly conserved among GPCRs, functions independently as an ER-export signal for the dopamine D1 receptor. A newly identified ER-membrane-associated protein, DRiP78, binds to this motif. Overexpression or… Expand
Regulation of Transport of the Angiotensin AT2 Receptor by a Novel Membrane-Associated Golgi Protein
TLDR
The results indicate that ATBP50 regulates the transport of the AT2R to cell membrane by binding to a specific motif within its cytoplasmic carboxy-terminal and thereby enabling the antiproliferative effects of the receptor. Expand
The anterograde transport of the human neuropeptide Y2 receptor is regulated by a subtype specific mechanism mediated by the C-terminus
TLDR
This work determined the role of the CT in the anterograde transport of the human neuropeptide Y receptor (hYR) type 2 and identified a short sequence motif in the membrane proximal CT: Y(x)(3)F(x)F in the region of the putative 8th helix has a critical functional relevance for the antersized transport of hY(2)R. Expand
The regulatory mechanisms of export trafficking of G protein-coupled receptors.
TLDR
This review will cover recent advances in understanding the mechanism underlying GPCR export trafficking by focusing on specific motifs required for ER export and the role of the Ras-like Rab1 GTPase and glycosylation in regulating ER-Golgi-cell-surface transport. Expand
Regulation of G protein-coupled receptor export trafficking.
TLDR
This review will cover recent advances in understanding the molecular mechanism underlying anterograde transport of the newly synthesized GPCRs from the endoplasmic reticulum through the Golgi to the plasma membrane, and focus on recently identified motifs involved in GPCR exit from the ER and the GolGI. Expand
Regulation of α2B-Adrenerigc Receptor Export Trafficking by Specific Motifs.
TLDR
Specific motifs identified to mediate the export of nascent α(2B)-AR from the ER and the Golgi are reviewed and they may provide common mechanisms for export trafficking of these receptors. Expand
ER-bound steps in the biosynthesis of G protein-coupled receptors.
TLDR
X-ray structures reveal a common polypeptide topology with little variation in the alignment and orientation of the seven transmembrane segments, the proximal carboxyl terminus (C-tail) and parts of the extracellular loops, which probably represents a major criterion for the receptor to pass endoplasmic reticulum (ER) quality control. Expand
Anterograde trafficking of nascent α(2B)-adrenergic receptor: structural basis, roles of small GTPases.
  • Guangyu Wu
  • Biology, Medicine
  • Current topics in membranes
  • 2011
TLDR
This chapter discusses the roles of recently identified motifs and the Sar1/ARF and Rab GTPases in α 2B -adrenergic receptor exit from intracellular organelles and transport from the endoplasmic reticulum (ER) to the cell surface. Expand
α2B-Adrenergic Receptor Interaction with Tubulin Controls Its Transport from the Endoplasmic Reticulum to the Cell Surface*
TLDR
The data provide the first evidence indicating that the α2B-AR C-terminal Arg cluster mediates its association with tubulin to coordinate its ER-to-cell surface traffic and suggest a novel mechanism of GPCR export through physical contact with microtubules. Expand
Novel regulatory mechanisms of D1 dopamine receptor maturation and internalization.
TLDR
This thesis explores how multimerization of D1DR has a role in regulating how G protein-coupled receptors are trafficked to the plasma membrane and suggests that specific conformational requirements must be achieved before full regulation. Expand
Regulation of Anterograde Transport of α2-Adrenergic Receptors by the N Termini at Multiple Intracellular Compartments*
TLDR
The Tyr-Ser motif, highly conserved in the membrane-proximal N termini of all α2-AR subtypes, is required for the exit of α2A-AR and α2B-AR from the Golgi apparatus, thus representing a novel Tyr-based motif modulating GPCR transport at the GolGI level. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 40 REFERENCES
Modulation of dopamine D(2) receptor signaling by actin-binding protein (ABP-280).
TLDR
A mechanism for a new molecular mechanism of modulating D(2) receptor signaling by cytoskeletal protein interaction is suggested, as determined by immunocytochemical analysis in ABP-deficient and replete cells. Expand
Multiple GTP-binding proteins regulate vesicular transport from the ER to Golgi membranes
TLDR
Results are consistent with the hypothesis that multiple GTP-binding proteins including a heterotrimeric G protein(s), ARF and rab1 differentially regulate steps in the transport of protein between early compartments of the secretory pathway. Expand
Effects of truncations of the cytoplasmic tail of the luteinizing hormone/chorionic gonadotropin receptor on receptor-mediated hormone internalization.
TLDR
It is suggested that a region(s) between residues 616 and 631 of the rLH/CG receptor are required for proper insertion and/or targeting of the receptor into the plasma membrane, and both hCG-stimulated cAMP production and hCG internalization are enhanced by the removal of the distal portion of the cytoplasmic tail. Expand
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
TLDR
It is shown that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a new family of single-trans Membrane-domain proteins, which are called receptor-activity-modifying proteins or RAMPs, are expressed. Expand
Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate.
TLDR
It is demonstrated that real-time optical measurements of beta2AR (as well as other GPCR) interactions and dynamics on living cells are feasible and fidelity of the biochemical properties of thebeta2AR/S65T/GFP can be engineered. Expand
Sorting Determinants in the Transmembrane Domain of p24 Proteins*
TLDR
The role of the transmembrane domain (TMD) of a p24 protein isolated from COPI-coated intra-Golgi transport vesicles is analyzed and TMD residues of p24 proteins may mediate the interaction with integral membrane proteins of the vesicle budding machinery to ensure p24 packaging into transportVesicles. Expand
Export from the Endoplasmic Reticulum Represents the Limiting Step in the Maturation and Cell Surface Expression of the Human δ Opioid Receptor*
TLDR
The overall low efficiency of receptor maturation, less than 50% of the precursor being processed to the fully glycosylated protein, suggests that only a fraction of the synthesized receptors attain properly folded conformation that allows exit from the ER. Expand
A G Protein-coupled Receptor for UDP-glucose*
TLDR
It is shown that UDP-glucose, and some closely related molecules, potently activate the orphan G protein-coupled receptor KIAA0001 heterologously expressed in yeast or mammalian cells, suggesting that some sugar-nucleotides may serve important physiological roles as extracellular signaling molecules in addition to their familiar role in intermediary metabolism. Expand
Folding and cell surface expression of the vasopressin V2 receptor: requirement of the intracellular C‐terminus
TLDR
The data suggest that residues in the N‐terminal part of the C‐terminus are necessary for correct folding and that C‐Terminal residues are important for efficient cell surface expression. Expand
A di-acidic signal required for selective export from the endoplasmic reticulum.
TLDR
The existence of a di-acidic signal on the cytoplasmic tail of vesicular stomatitis virus glycoprotein and other cargo molecules was required for efficient recruitment to vesicles mediating export from the ER in baby hamster kidney cells and provides evidence that exportFrom the ER occurs through a selective mechanism. Expand
...
1
2
3
4
...