Regulation of transient receptor potential channels by the phospholipase C pathway.

  title={Regulation of transient receptor potential channels by the phospholipase C pathway.},
  author={Tibor Rohacs},
  journal={Advances in biological regulation},
  volume={53 3},
Transient Receptor Potential (TRP) channels were discovered while analyzing visual mutants in Drosophila. The protein encoded by the transient receptor potential (trp) gene is a Ca(2+) permeable cation channel activated downstream of the phospholipase C (PLC) pathway. While searching for homologs in other organisms, a surprisingly large number of mammalian TRP channels was cloned. The regulation of TRP channels is quite diverse, but many of them are either activated downstream of PLC, or… CONTINUE READING

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Publications referenced by this paper.
Showing 1-10 of 178 references

TRPV1 trafficking to the plasma membrane

BC Suh, B. Hille
J Gen Physiol • 2008
View 4 Excerpts
Highly Influenced

Phosphoinositide regulation of TRP channels.

Handbook of experimental pharmacology • 2014
View 2 Excerpts

Desensitization of coldand mentholsensitive rat dorsal root ganglion neurones by in fl ammatory mediators

RM Linte, C Ciobanu, G Reid, A Babes
Exp Brain Res • 2013

Distinctive changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2013
View 7 Excerpts

TRPC 1 forms the stretchactivated cation channel in vertebrate cells

R Maroto, A Raso, +3 authors OP Hamill
Nat Cell Biol • 2013

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