Regulation of transient receptor potential canonical channel 1 (TRPC1) by sphingosine 1-phosphate in C2C12 myoblasts and its relevance for a role of mechanotransduction in skeletal muscle differentiation.

@article{Formigli2009RegulationOT,
  title={Regulation of transient receptor potential canonical channel 1 (TRPC1) by sphingosine 1-phosphate in C2C12 myoblasts and its relevance for a role of mechanotransduction in skeletal muscle differentiation.},
  author={Lucia Formigli and Chiara Sassoli and Roberta Squecco and Francesca Bini and Maria Martinesi and Flaminia Chellini and Giorgia Luciani and Francesca Sbrana and Sandra Zecchi-Orlandini and Fabio Francini and Elisabetta Meacci},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 9},
  pages={1322-33}
}
Transient receptor potential canonical (TRPC) channels provide cation and Ca(2+) entry pathways, which have important regulatory roles in many physio-pathological processes, including muscle dystrophy. However, the mechanisms of activation of these channels remain poorly understood. Using siRNA, we provide the first experimental evidence that TRPC channel 1 (TRPC1), besides acting as a store-operated channel, represents an essential component of stretch-activated channels in C2C12 skeletal… CONTINUE READING