Regulation of transforming growth factor-beta activation by discrete sequences of thrombospondin 1.

@article{SchultzCherry1995RegulationOT,
  title={Regulation of transforming growth factor-beta activation by discrete sequences of thrombospondin 1.},
  author={Stacey Schultz-Cherry and Hong Chen and Deane F Mosher and Tina M Misenheimer and Henry C. Krutzsch and David D. Roberts and Joanne E Murphy-Ullrich},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 13},
  pages={7304-10}
}
Transforming growth factor-beta (TGF-beta) is a potent growth regulatory protein secreted by virtually all cells in a latent form. A major mechanism of regulating TGF-beta activity occurs through factors that control the processing of the latent to the biologically active form of the molecule. We have shown previously that thrombospondin 1 (TSP1), a platelet alpha-granule and extracellular matrix protein, activates latent TGF-beta via a protease- and cell-independent mechanism and have… CONTINUE READING
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