Regulation of transforming growth factor β1-dependent aldose reductase expression by the Nrf2 signal pathway in human mesangial cells.

@article{Wang2012RegulationOT,
  title={Regulation of transforming growth factor β1-dependent aldose reductase expression by the Nrf2 signal pathway in human mesangial cells.},
  author={Fei Wang and Fei Tian and Samantha A. Whitman and Donna D. Zhang and Toru Nishinaka and Nong Zhang and Tao Jiang},
  journal={European journal of cell biology},
  year={2012},
  volume={91 10},
  pages={774-81}
}
Aldose reductase (AR) is a key enzyme in the alternative glucose metabolism pathway, the polyol pathway. To date, AR is known to be involved in several secondary complications of diabetes and various kidney diseases. The goal of this study was to elucidate how the Nrf2-anti-oxidant response element (ARE) signal pathway plays a role in TGFβ1's regulation of AR expression in human renal mesangial cells (HRMCs). As an in vitro model system, HRMCs were used to investigate AR mRNA by qPCR, protein… CONTINUE READING