Regulation of transcription factors c-Myc, Max, and c-Myb by casein kinase II.

@article{Bousset1994RegulationOT,
  title={Regulation of transcription factors c-Myc, Max, and c-Myb by casein kinase II.},
  author={K Bousset and Michael Oelgeschl{\"a}ger and Marie Engstr{\"o}m Henriksson and Sabine Schreek and Hans Burkhardt and David W. Litchfield and Juliane M L{\"u}scher-Firzlaff and Bernhard L{\"u}scher},
  journal={Cellular & molecular biology research},
  year={1994},
  volume={40 5-6},
  pages={501-11}
}
A number of transcription factors have been shown to be phosphorylated by casein kinase II (CKII). We have identified CKII phosphorylation sites in c-Myc, Max, and c-Myb which are phosphorylated in the cell. Whereas little evidence to any functional significance of the CKII sites in c-Myc has been obtained, phosphorylation of its heterodimeric partner Max alters DNA binding properties. CKII phosphorylation of Ser-2 and -11 in Max resulted in enhanced DNA binding kinetics of both Max/Max homo… CONTINUE READING

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