Regulation of transcription factors by neuronal activity

  title={Regulation of transcription factors by neuronal activity},
  author={Anne E West and Eric C. Griffith and Michael E. Greenberg},
  journal={Nature Reviews Neuroscience},
Synaptic activity regulates the expression of a set of neuronal gene products that are important for neuronal survival and differentiation, synaptogenesis and, ultimately, complex behaviour. Activity-dependent signalling pathways induce neuronal gene transcription by modulating the function of both transcriptional activators and repressors, and recent studies have revealed significant diversity in the mechanisms that control the activity of these transcriptional regulators. Investigators have… CONTINUE READING
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