Regulation of toll-like receptor 2 expression by macrophages following Mycobacterium avium infection.

@article{Wang2000RegulationOT,
  title={Regulation of toll-like receptor 2 expression by macrophages following Mycobacterium avium infection.},
  author={Tianyi Wang and William P. Lafuse and Bruce S. Zwilling},
  journal={Journal of immunology},
  year={2000},
  volume={165 11},
  pages={6308-13}
}
Recent studies have implicated Toll-like receptors (TLR), especially TLR2 and TLR4, as sentinel receptors that signal the interaction of macrophages with bacterial pathogens via a NF-kappaB-mediated pathway. The regulation of TLR gene expression, however, has not been intensively studied. Here, we report that TLR2 mRNA was induced following infection of murine macrophages with Mycobacterium avium. The changes in TLR2 mRNA correlated with an increase in TLR2 surface expression. Infection with M… CONTINUE READING