Regulation of tissue transglutaminase gene expression as a molecular model for retinoid effects on proliferation and differentiation.

@article{Chiocca1989RegulationOT,
  title={Regulation of tissue transglutaminase gene expression as a molecular model for retinoid effects on proliferation and differentiation.},
  author={E Antonio Chiocca and Peter Davies and Joseph P Stein},
  journal={Journal of cellular biochemistry},
  year={1989},
  volume={39 3},
  pages={293-304}
}
Retinoids (structural and functional analogs of vitamin A) are potent antiproliferative agents whose mode of action is poorly understood. It has been suggested that the molecular events that underscore their action involve alterations in gene expression, but no gene has yet been shown to be directly regulated by these molecules. Several years ago, we found that retinoic acid caused an accumulation of the enzyme tissue transglutaminase in murine peritoneal macrophages and in human promyelocytic… CONTINUE READING
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