Regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 (LSD1 and LSD2)

@article{Mino2014RegulationOT,
  title={Regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 (LSD1 and LSD2)},
  author={Koshiki Mino and Satoshi Nishimura and Shogo Ninomiya and Hiroshi Tujii and Yasumasa Matsumori and Mie Tsuchida and Miho Hosoi and Koichi Koseki and Shu-ichi Wada and Makoto Hasegawa and Ryuzo Sasaki and Yukie Murakami-Yamaguchi and Hiroshi Narita and Takayoshi Suzuki and Naoki Miyata and Tamio Mizukami},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2014},
  volume={78},
  pages={1010 - 1017}
}
Tissue factor pathway inhibitor-2 (TFPI-2) is a major inhibitor of extracellular matrix degradation. Decreases in TFPI-2 contribute to malignant tumor cell production, and TFPI-2 is a presumed tumor suppressor. TFPI-2 gene transcription is regulated by two epigenetic mechanisms: DNA methylation of the promoter and K4 methylation of histone 3 (H3). Lysine-specific demethylase 1 (LSD1) and LSD2 demethylate H3K4me2/1. LSD1 has been implicated in TFPI-2 regulation through both epigenetic mechanisms… 
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13 Citations

Lysine-specific demethylase 2 contributes to the proliferation of small cell lung cancer by regulating the expression of TFPI-2

The results suggest that LSD2 achieves a promoting effect on SCLC by indirectly regulating TFPI-2 expression through the mediation of DNMT3B expression or through the regulation of the demethylation of H3K4me1 in the promoter region of the TFPi-2 gene.

Estrogen induced expression of tissue factor pathway inhibitor-2 in MCF7 cells involves lysine-specific demethylase 1

LSD 2 / KDM 1 B / AOF 1 and Human Cancer Pathways : A Literature Review

Five major studies on LSD2 in cancer indicate that LSD2 may play multiple roles in human cancer cell survival and may play a crucial role in understanding pathways that illuminate novel treatments for human cancer.

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This review focuses on published small-molecule inhibitors targeted at the two flavin adenine dinucleotide-dependent lysine demethylase 1 and 2, and how the inhibitors interact with the tertiary structures of the enzymes.

S‐adenosylmethionine in combination with decitabine shows enhanced anti‐cancer effects in repressing breast cancer growth and metastasis

The combined therapeutic effects of an approved nutraceutical agent S‐adenosylmethionine and FDA‐approved hypomethylating agent decitabine using the MDA‐MB‐231 xenograft model of breast cancer is investigated and found a pronounced reduction in mammary tumour volume and lung metastasis compared to the animals in the control and monotherapy treatment arms.

Tissue Factor Pathway Inhibitor-2 Gene Polymorphisms Associate With Coronary Atherosclerosis in Chinese Population tissue factor–factor

There was not enough evidence showing that the information about TFPI-2 gene polymorphisms was useful for assessing the risk of developing coronary atherosclerosis, but there was notenough evidence showing it could predict occurrence of CVE.

Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide.

Tissue Factor Pathway Inhibitor-2 Gene Polymorphisms Associate With Coronary Atherosclerosis in Chinese Population

Tissue factor pathway inhibitor-2 gene polymorphisms were associated with coronary atherosclerosis in the Chinese population, suggesting that the information about TFPI-2 Gene polymorphisms was useful for assessing the risk of developing coronary Atherosclerosis, but there was not enough evidence showing it could predict occurrence of CVE.

Identification of ryuvidine as a KDM5A inhibitor

Ryuvidine may serve as a lead compound for KDM5 targeted therapeutics after it was found that ryuvidine prevented generation of gefitinib-tolerant human small-cell lung cancer PC9 cells and also inhibited the growth of the drug-Tolerant cells at concentrations that did not affect thegrowth of parentalPC9 cells.

Interaction between tissue factor pathway inhibitor-2 gene polymorphisms and environmental factors associated with coronary atherosclerosis in a Chinese Han

The GMDR model shown the best models for gene–environment interaction were rs34489123 and smoking after adjusting the covariates, which scored 10 out of 10 for cross-validation consistency and 0.0010 for the sign test.

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