Regulation of tissue factor and inflammatory mediators by Egr-1 in a mouse endotoxemia model.

@article{Pawlinski2003RegulationOT,
  title={Regulation of tissue factor and inflammatory mediators by Egr-1 in a mouse endotoxemia model.},
  author={Rafal Pawlinski and Brian Pedersen and Bettina Kehrle and William C. Aird and Rolf Dario Frank and Mausumee Guha and Nigel Mackman},
  journal={Blood},
  year={2003},
  volume={101 10},
  pages={3940-7}
}
In septic shock, tissue factor (TF) activates blood coagulation, and cytokines and chemokines orchestrate an inflammatory response. In this study, the role of Egr-1 in lipopolysaccharide (LPS) induction of TF and inflammatory mediators in vivo was evaluated using Egr-1(+/+) and Egr-1(-/-) mice. Administration of LPS transiently increased the steady-state levels of Egr-1 mRNA in the kidneys and lungs of Egr-1(+/+) mice with maximal induction at one hour. Egr-1 was expressed in epithelial cells… CONTINUE READING

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