Regulation of tight junction permeability with switch-like speed.

  title={Regulation of tight junction permeability with switch-like speed.},
  author={Klaus W Beyenbach},
  journal={Current opinion in nephrology and hypertension},
  volume={12 5},
PURPOSE OF REVIEW The case is made that tight junctions can undergo large reversible conductance changes in a matter of seconds and yet preserve their permselectivity. The diuretic peptide leucokinin transforms (renal) Malpighian tubules of the yellow fever mosquito from a moderately tight epithelium to a leaky epithelium by increasing the chloride-conductance of the paracellular shunt pathway. The nine-fold increase in the paracellular chloride-conductance brings about a non-selective… CONTINUE READING


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