Regulation of tight junction permeability by intestinal bacteria and dietary components.

  title={Regulation of tight junction permeability by intestinal bacteria and dietary components.},
  author={Dulantha Ulluwishewa and Rachel Claire Anderson and Warren C. McNabb and Paul J. Moughan and Jerry M Wells and Nicole C. Roy},
  journal={The Journal of nutrition},
  volume={141 5},
The human intestinal epithelium is formed by a single layer of epithelial cells that separates the intestinal lumen from the underlying lamina propria. The space between these cells is sealed by tight junctions (TJ), which regulate the permeability of the intestinal barrier. TJ are complex protein structures comprised of transmembrane proteins, which interact with the actin cytoskeleton via plaque proteins. Signaling pathways involved in the assembly, disassembly, and maintenance of TJ are… 

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