Regulation of thromboxane receptor activation in human platelets.


Thromboxane A2 (TxA2) is a potent platelet agonist that serves as an amplifying signal after exposure of platelets to other stimulants, such as thrombin, in vitro. Exposure of platelets to the TxA2 receptor agonists U46619 and SQ 26,655 (1.4 microM) resulted in a 60-90% decrease in subsequent TxA2 receptor-stimulated aggregation, calcium release, and… (More)


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@article{Murray1989RegulationOT, title={Regulation of thromboxane receptor activation in human platelets.}, author={Robin M. Murray and Garret A. FitzGerald}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1989}, volume={86 1}, pages={124-8} }