Regulation of thick ascending limb transport: role of nitric oxide.

  title={Regulation of thick ascending limb transport: role of nitric oxide.},
  author={Marcela Herrera and Pablo Alfredo Ortiz and Jeffrey L. Garvin},
  journal={American journal of physiology. Renal physiology},
  volume={290 6},
Nitric oxide (NO) plays a role in many physiological and pathophysiological processes. In the kidney, NO reduces renal vascular resistance, increases glomerular filtration rate, alters renin release, and inhibits transport along the nephron. The thick ascending limb is responsible for absorbing 20-30% of the filtered load of NaCl, much of the bicarbonate that escapes the proximal nephron, and a significant fraction of the divalent cations reclaimed from the forming urine. Additionally, this… CONTINUE READING


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Laminar flow stimulates ATP- and shear stress-dependent Invited Review F1283 NO AND THAL TRANSPORT AJP-Renal Physiol

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