Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2.

@article{Ekberg2007RegulationOT,
  title={Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2.},
  author={Jenny A. K. Ekberg and Friderike Schuetz and Natasha Anne Boase and S C Conroy and Jantina A. Manning and Sharad Kumar and Philip Poronnik and David J Adams},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 16},
  pages={12135-42}
}
The muscarine-sensitive K(+) current (M-current) stabilizes the resting membrane potential in neurons, thus limiting neuronal excitability. The M-current is mediated by heteromeric channels consisting of KCNQ3 subunits in association with either KCNQ2 or KCNQ5 subunits. The role of KCNQ2/3/5 in the regulation of neuronal excitability is well established; however, little is known about the mechanisms that regulate the cell surface expression of these channels. Ubiquitination by the Nedd4/Nedd4-2… CONTINUE READING

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