Regulation of the type III InsP3 receptor and its role in beta cell function.

@article{Hagar2000RegulationOT,
  title={Regulation of the type III InsP3 receptor and its role in beta cell function.},
  author={Robert E. Hagar and Barbara E Ehrlich},
  journal={Cellular and molecular life sciences : CMLS},
  year={2000},
  volume={57 13-14},
  pages={1938-49}
}
The type III inositol 1,4,5-trisphosphate receptor (InsP3R) is an important intracellular calcium (Ca2+) release channel in the pancreatic beta cell. Pancreatic beta cells secrete insulin following a characteristic change in membrane potential that leads to an increase in cytoplasmic Ca2+. Both extracellular Ca2+ and Ca2+ mobilized from InsP3-sensitive… CONTINUE READING