Regulation of the tumor suppressor homeogene Cdx2 by HNF4α in intestinal cancer

Abstract

The gut-specific homeotic transcription factor Cdx2 is a crucial regulator of intestinal development and homeostasis, which is downregulated in colorectal cancers (CRC) and exhibits a tumor suppressor function in the colon. We have previously established that several endodermal transcription factors, including HNF4α and GATA6, are involved in Cdx2… (More)
DOI: 10.1038/onc.2012.401

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