Regulation of the tumor marker Fascin by the viral oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) depends on promoter activation and on a promoter-independent mechanism.

@article{Mohr2015RegulationOT,
  title={Regulation of the tumor marker Fascin by the viral oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) depends on promoter activation and on a promoter-independent mechanism.},
  author={Caroline F Mohr and Christine Gross and Matthias Bros and Angelika Reske-Kunz and Brigitte Biesinger and Andrea K. Thoma-Kre\ss},
  journal={Virology},
  year={2015},
  volume={485},
  pages={481-91}
}
Adult T-cell leukemia/lymphoma is a highly infiltrative neoplasia of CD4(+) T-lymphocytes that occurs in about 5% of carriers infected with the deltaretrovirus human T-cell leukemia virus type 1 (HTLV-1). The viral oncoprotein Tax perturbs cellular signaling pathways leading to upregulation of host cell factors, amongst them the actin-bundling protein… CONTINUE READING