Regulation of the transcription factor c-JUN by nerve growth factor in adult sensory neurons.

@article{Gold1993RegulationOT,
  title={Regulation of the transcription factor c-JUN by nerve growth factor in adult sensory neurons.},
  author={Bruce G. Gold and Toni L. Storm-Dickerson and David R. Austin},
  journal={Neuroscience letters},
  year={1993},
  volume={154 1-2},
  pages={129-33}
}
We examined the regulation by nerve growth factor (NGF) of the immediate-early gene (proto-oncogene) c-jun in adult dorsal root ganglion (DRG) neurons using immunocytochemistry to c-JUN (the protein product of the proto-oncogene c-jun). Following a sciatic nerve crush, the injury-induced increase in c-JUN-like immunostaining was reduced in DRG neurons by continuous intrathecal infusion of NGF for one week. Conversely, in intact DRG neurons (i.e., without Wallerian degeneration), c-JUN-like… CONTINUE READING

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