Regulation of the tolerogenic function of steady-state DCs.

  title={Regulation of the tolerogenic function of steady-state DCs.},
  author={Hans Christian Probst and Sabine Muth and Hansjoerg Schild},
  journal={European journal of immunology},
  volume={44 4},
Dendritic cells (DCs) are master regulators of T-cell responses. After sensing pathogen-derived molecular patterns (PAMPs), or signals of inflammation and cellular stress, DCs differentiate into potent activators of naïve CD4(+) and CD8(+) T cells through a process that is termed DC maturation. By contrast, DCs induce and maintain peripheral T-cell tolerance in the steady state, that is in the absence of overt infection or inflammation. However, the immunological steady state is not devoid of… CONTINUE READING
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