Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway

Abstract

Apoptosis signal-regulating kinase 1 (ASK1) is an evolutionarily conserved mitogen-activated protein kinase (MAPK) kinase kinase which plays important roles in stress and immune responses. Here, we show that ASK1 deficiency attenuates neuroinflammation in experimental autoimmune encephalomyelitis (EAE), without affecting the proliferation capability of T… (More)
DOI: 10.1002/emmm.201000103

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