Regulation of the serotonin transporter by interacting proteins.

  title={Regulation of the serotonin transporter by interacting proteins.},
  author={J. Haase and A. Killian and F. Magnani and C. Williams},
  journal={Biochemical Society transactions},
  volume={29 Pt 6},
  • J. Haase, A. Killian, +1 author C. Williams
  • Published 2001
  • Medicine, Biology
  • Biochemical Society transactions
  • The serotonin transporter (SERT) plays a critical role in the maintenance of normal neurotransmission by serotonin [5-hydroxytryptamine (5-HT)]. Recent evidence suggests that SERT and other neurotransmitter transporters are tightly regulated. Activation of protein kinase C results in a decrease in SERT-mediated 5-HT uptake, which is due to an internalization of the transporter. However, to date little is known about the mechanism and proteins involved in the down-regulation of the transporter… CONTINUE READING
    SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation
    • 506
    • PDF
    Membrane Glycoprotein M6B Interacts with the Human Serotonin Transporter
    • 32
    • Highly Influenced
    Regulating the Conducting States of a Mammalian Serotonin Transporter
    • 145