Regulation of the serotonin transporter by interacting proteins.

  title={Regulation of the serotonin transporter by interacting proteins.},
  author={Jana Haase and Audrey Killian and Francesca Magnani and C. S. Williams},
  journal={Biochemical Society transactions},
  volume={29 Pt 6},
The serotonin transporter (SERT) plays a critical role in the maintenance of normal neurotransmission by serotonin [5-hydroxytryptamine (5-HT)]. Recent evidence suggests that SERT and other neurotransmitter transporters are tightly regulated. Activation of protein kinase C results in a decrease in SERT-mediated 5-HT uptake, which is due to an internalization of the transporter. However, to date little is known about the mechanism and proteins involved in the down-regulation of the transporter… CONTINUE READING
36 Citations
1 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 36 extracted citations


Publications referenced by this paper.

Nature (London) 390

  • J Pevsner., M. K. Bennett, M. W. Benos. D. 1.. Quick, L KirkK.
  • Nature (London)
  • 1997

Similar Papers

Loading similar papers…