Regulation of the serotonin transporter by interacting proteins.

@article{Haase2001RegulationOT,
  title={Regulation of the serotonin transporter by interacting proteins.},
  author={Jana Haase and Audrey Killian and Francesca Magnani and C. S. Williams},
  journal={Biochemical Society transactions},
  year={2001},
  volume={29 Pt 6},
  pages={722-8}
}
The serotonin transporter (SERT) plays a critical role in the maintenance of normal neurotransmission by serotonin [5-hydroxytryptamine (5-HT)]. Recent evidence suggests that SERT and other neurotransmitter transporters are tightly regulated. Activation of protein kinase C results in a decrease in SERT-mediated 5-HT uptake, which is due to an internalization of the transporter. However, to date little is known about the mechanism and proteins involved in the down-regulation of the transporter… CONTINUE READING
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