Regulation of the secretory response in bovine chromaffin cells.

@article{Callewaert1991RegulationOT,
  title={Regulation of the secretory response in bovine chromaffin cells.},
  author={Geert Callewaert and Ross G. Johnson and Martin Morad},
  journal={The American journal of physiology},
  year={1991},
  volume={260 4 Pt 1},
  pages={C851-60}
}
The nicotine-induced current and the Ca2+ current were studied in cultured bovine chromaffin cells using the whole cell patch-clamp technique. The dose-response curve for the nicotinic current gave a dissociation constant of 53 microM and a Hill coefficient of 1.3. Desensitization of the nicotinic current was rapid, with time constants of 22 and 155 ms at… CONTINUE READING