Regulation of the sarcoplasmic reticulum Ca2+-ATPase expression in the hypertrophic and failing heart.

@article{ZarainHerzberg2006RegulationOT,
  title={Regulation of the sarcoplasmic reticulum Ca2+-ATPase expression in the hypertrophic and failing heart.},
  author={Angel Zarain-Herzberg},
  journal={Canadian journal of physiology and pharmacology},
  year={2006},
  volume={84 5},
  pages={509-21}
}
The sarcoplasmic reticulum (SR) plays a central role in the contraction and relaxation coupling in the myocardium. The SR Ca(2+)-ATPase (SERCA2) transports Ca(2+) inside the SR lumen during relaxation of the cardiac myocyte. It is well known that diminished contractility of the hypertrophic cardiac myocyte is the main factor of ventricular dysfunction in… CONTINUE READING