Regulation of the proliferation and differentiation of Leydig stem cells in the adult testis.

@article{Odeh2014RegulationOT,
  title={Regulation of the proliferation and differentiation of Leydig stem cells in the adult testis.},
  author={Hana M. Odeh and Colin Kleinguetl and Renshan Ge and Barry R. Zirkin and Haolin Chen},
  journal={Biology of reproduction},
  year={2014},
  volume={90 6},
  pages={123}
}
We reported previously that stem cells associated with adult rat testis seminiferous tubules are able to give rise to differentiated Leydig cells in vitro. The regulatory mechanisms by which they do so, however, are uncertain. Herein, we hypothesized that the proliferation and differentiation of Leydig cell stem cells (stem Leydig cells, SLCs) depend upon locally produced factors from the seminiferous tubules. Microarray analysis revealed that platelet-derived growth factor receptor alpha… CONTINUE READING
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