Regulation of the on bipolar cell mGluR6 pathway by Ca2+.

@article{Nawy2000RegulationOT,
  title={Regulation of the on bipolar cell mGluR6 pathway by Ca2+.},
  author={Scott Nawy},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 12},
  pages={
          4471-9
        }
}
Glutamate produces a hyperpolarizing synaptic potential in On bipolar cells by binding to the metabotropic glutamate receptor mGluR6, leading to closure of a cation channel. Here it is demonstrated that this cation channel is regulated by intracellular Ca(2+). Glutamate-evoked currents were recorded from On bipolar cells in light-adapted salamander retinal slices in the presence of 2 mm external Ca(2+). When glutamate was applied almost continuously, interrupted only briefly to measure the size… CONTINUE READING

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