Regulation of the nucleotide state of the Rho GTPases is accomplished by the action of three major classes of proteins: guanine nucleotide exchange factors, guanine nucleotide dissociation inhibitors and GTPase activating proteins (GAPs)


Members of the Rho family of small GTPases, which includes the Rho, Rac and Cdc42 proteins, function as critical regulators of actin cytoskeleton organization. As such, these proteins mediate a variety of cellular processes, including migration, adhesion and shape change (Hall, 1998; Van Aelst and D’Souza-Schorey, 1997). These cellular functions of the Rho… (More)


9 Figures and Tables