Regulation of the nucleosome unwrapping rate controls DNA accessibility

@inproceedings{North2012RegulationOT,
  title={Regulation of the nucleosome unwrapping rate controls DNA accessibility},
  author={Justin A. North and John C. Shimko and Sarah Javaid and Alex M. Mooney and Matthew A. Shoffner and Sean Rose and Ralf Bundschuh and Richard Prof Fishel and Jennifer J. Ottesen and Michael G Poirier},
  booktitle={Nucleic acids research},
  year={2012}
}
Eukaryotic genomes are repetitively wrapped into nucleosomes that then regulate access of transcription and DNA repair complexes to DNA. The mechanisms that regulate extrinsic protein interactions within nucleosomes are unresolved. We demonstrate that modulation of the nucleosome unwrapping rate regulates protein binding within nucleosomes. Histone H3 acetyl-lysine 56 [H3(K56ac)] and DNA sequence within the nucleosome entry-exit region additively influence nucleosomal DNA accessibility by… CONTINUE READING

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