Regulation of the nisin operons in Lactococcus lactis N8.

  title={Regulation of the nisin operons in Lactococcus lactis N8.},
  author={M. Qiao and Sheng Huan Ye and Olli Koponen and Runar Ra and M Usabiaga and Tiina Immonen and Per Erik Joakim Saris},
  journal={The Journal of applied bacteriology},
  volume={80 6},
The antibiotic peptide nisin produced by Lactococcus lactis is used as a food preservative due to its activity against spores and vegetative cells of Gram-positive bacteria. The post-translational maturation of this secreted peptide includes dehydration of serine and threonine residues, lanthionine formation and a proteolytic processing of 23 amino acids from the N-terminus. Mutations in the nisZ, nisB and nisP genes of the biosynthetic nisZBTCIPRK nisin operon were made by gene replacement or… CONTINUE READING