Regulation of the muscle fiber microenvironment by activated satellite cells during hypertrophy.

@article{Fry2014RegulationOT,
  title={Regulation of the muscle fiber microenvironment by activated satellite cells during hypertrophy.},
  author={Christopher S Fry and Jonah D. Lee and Janna R. Jackson and Tyler J. Kirby and Shawn A Stasko and Honglu Liu and Esther E Dupont-Versteegden and John J McCarthy and Charlotte A. Peterson},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2014},
  volume={28 4},
  pages={1654-65}
}
Our aim in the current study was to determine the necessity of satellite cells for long-term muscle growth and maintenance. We utilized a transgenic Pax7-DTA mouse model, allowing for the conditional depletion of > 90% of satellite cells with tamoxifen treatment. Synergist ablation surgery, where removal of synergist muscles places functional overload on the plantaris, was used to stimulate robust hypertrophy. Following 8 wk of overload, satellite cell-depleted muscle demonstrated an… CONTINUE READING
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