Regulation of the murine renal vitamin D receptor by 1,25-dihydroxyvitamin D3 and calcium.

@article{Healy2003RegulationOT,
  title={Regulation of the murine renal vitamin D receptor by 1,25-dihydroxyvitamin D3 and calcium.},
  author={Kevin D Healy and Julia B. Zella and Jean M. Prahl and Hector F DeLuca},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 17},
  pages={
          9733-7
        }
}
Renal vitamin D receptor (VDR) is required for 1,25-dihydroxyvitamin D3-[1,25(OH)2D3]-induced renal reabsorption of calcium and for 1,25(OH)2D3-induced 1,25(OH)2D3 24-hydroxylase. The long-term effect of vitamin D and dietary calcium on the expression of renal VDR was examined in the nonobese diabetic mouse. Vitamin D-deficient and vitamin D-replete mice were maintained on diets containing 0.02%, 0.25%, 0.47%, and 1.20% calcium with or without 50 ng of 1,25(OH)2D3 per day. Vitamin D-replete… CONTINUE READING

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